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6 Low dose may be better tolerated though less well studied for CVD effects

Although this risk has been observed in animal studies, its not yet confirmed in humans

How clinicians can incorporate l-carnitine Health professionals can view l-carnitine as an adjunctive tool

Since both glucose and fatty acids could contribute to histone acetylation, we reasoned that this could occur either by two distinct substrate-specific mechanisms or a mechanism in which these substrates can feed into a common precursor acetyl-CoA pool (e.g., in mitochondria) that is then transported to the nuclear-cytosolic compartment (Supplemental Figure 5E)