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Separate acute from chronic, and put a boundary on duration If someone is intent on using it, the least risky scenario is short-term use around a clearly defined acute injury window, not ongoing use for months for chronic pain

This research was funded by the National Science Fund for Distinguished Young Scholars of China (31525024), National Natural Science Fund of China (31902379) and the China Agriculture Research System (CARS47-11), National Key Research and Development Program of China (2018YFD0900402), and Key Research and Development Project of Shandong Province (2019JZZY010814)

Thus, they may lead to clinical improvement even in patients without significant shifts in metabolism

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