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Prevention of Chronic Adaptation When Achilles injuries fail to heal properly, the tendon undergoes degenerative changes that become increasingly difficult to reverse

The most common reasons include: Gastrointestinal side effects such as nausea, vomiting and diarrhea which are the single most frequently documented reason for stopping in large health system datasets High out of pocket cost and lack of insurance coverage particularly in individuals without diabetes Medication unavailability or pharmacy supply shortages which peaked in 2023early 2024 Perceived completion of therapy once target weight is reached or weight loss plateaus Concerns about long term safety or treatment burden of injections Many cohorts show substantial discontinuation by 3 months, with further losses by 6-9 months

When this fat diminishes quickly, the skin may sag and wrinkle, leading to a more aged appearance

Starting with a lower dose and gradually increasing it can help minimize bloating