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HIF-1 activates glycolysis-related genes, including pyruvate dehydrogenase kinase 1 (PDK1), increasing the conversion of glucose to pyruvate and subsequently to lactate by inactivating PDH, which is considered critical for metabolic adaptation to hypoxia [74] [Figure 1F]
JACC Asia 2 , 287293 (2022)
A CobaSorb test showing a clear increase in holoTC supports a normal uptake, while an increase below a set limit should be taken with some reservation before a conclusion of a permanent impaired uptake of B12 is made
A low-carbohydrate, high-fat diet leads to unfavorable changes in blood lipid profiles compared to carbohydrate-rich diets with different glycemic indices in recreationally active men
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