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Progressive food-seeking behavior and hyperphagia are observed in association with constant and inexorable hunger, which can lead to life-threatening obesity in adults with PWS [10]

GIP receptor activation plays a different but equally important role by: Improving insulin sensitivity at the cellular level , allowing cells to respond more effectively to insulin Enhancing fat metabolism and reducing signals that promote fat storage Reducing post-meal glucose spikes by improving glucose disposal This second pathway directly addresses one of the core drivers of insulin resistance: poor cellular response to insulin despite high circulating levels

The evidence base for this blend is preclinical and indirect