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Pediatrics 1994;93:893-5

In reaction to AD, astrocytes experience a shift in profile, one that is reactive and pro-inflammatory while losing homeostatic roles thus disrupting BBB integrity, ion and neurotransmitter buffering, and energy metabolism (Liddelow et al., 2017

Accumulating preclinical evidence indicates that the induction of ferroptosis may serve as a viable therapeutic strategy to combat tumour growth and enhance drug resistance

This scenario correlates well with the high request of ATP by the kidney to remove waste from the blood, to reabsorb nutrients, to modulate the balance of electrolytes and fluid, to maintain the acid-base homeostasis, and to regulate the blood pressure (Bhargava and Schnellmann, 2017)