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Nutrient IM injections are administered quicklytypically in under five minutesas a simple intramuscular injection, usually in the upper arm or gluteal muscle

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NICE guidance prioritises SGLT2 inhibitors for those with established or high risk of cardiovascular or kidney disease, with GLP-1 receptor agonists as add-on or alternative therapy where appropriate

Another limitation of our study is that we only compared drug effects using snRNA-seq after single acute drug treatment, hence not allowing conclusions on transcriptomic changes after more chronic treatment