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p53 is nicknamed the guardian of the genome because it is a tumor supressor when it detects mutation in the cells DNA (which can turn the cell into cancer), it causes apoptosis (in fact, lots of cancers are associated with genetic mutations that switch off p53, meaning that p53 stops working and cant kill the cell before it forms a tumor and possibly becomes cancerous)
Su funcin biolgica se relaciona con la adaptacin tisular especfica, ms que con efectos globales de crecimiento
These data indicate that dysfunctional and premature senescent hepatocytes, induced by oxidative stress, likely initiate liver damage and fibrogenesis
