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The Lancet 397:22842303
The one piece of cleaner support is Sun 2021 (PMID 34827486), an independent group's APP/PS1 mouse study reporting improved Morris water maze performance, increased synaptophysin, and reduced IL-1/TNF- via PI3K/AKT
10.3390/antiox10081270 102 MillerM
IL-1 then activates pyroptosis by binding to its receptor on the cell membrane, resulting in the formation of gasdermin D (GSDMD) pores that cause cell membrane rupture and the release of proinflammatory cytokines and damage-associated molecular patterns (DAMPs), such as high-mobility group box 1, heat shock proteins, and fibronectin advanced glycation end-products IL-33
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