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Patients with obesity-related heart failure, particularly HFpEF, who experience symptoms like breathlessness and reduced exercise capacity, may also benefit as emerging evidence suggests these therapies can improve symptoms and quality of life.Who should avoid them or exercise caution before use

Important: Both medications include a boxed warning and should be avoided in patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN 2)

Summary: This preclinical study investigated the mechanism of action of Cagrilintide in animal models

8.6 Limitations of the current evidence base Several limitations of the current evidence base should be acknowledged