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It is an , -unsaturated aldehyde that is released during the breakdown of petroleum fuels, biofuel, plastic, paper, and wood ( in vivo and in vitro has shown that acrolein causes oxidative stress, resulting in the rupture of cell membranes, DNA and mitochondria damage, endoplasmic reticulum (ER) stress, and the potential to initiate apoptosis ( , KC, MCP-1, 5-lipoxygenase, LTB4, and MMP, resulting in tissue damage and inflammation (114, 117)

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Paroxetine inhibits CYP2D6 and may reduce tamoxifen effectiveness, so venlafaxine is preferred for breast cancer patients on tamoxifen