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In certain embodiments, the pharmacokinetics of the otic formulations or compositions described herein are determined by injecting the formulation on or near the round window membrane of a test animal (including by way of example, a guinea pig, a chinchilla, or a rat)

Additional clusters were identified around the putamen, the right parahippocampal region and amygdala, the red nucleus in the midbrain, and the substantia nigra

Particularly, GLP-1 activates the AMPK signaling cascade by binding to skeletal muscle GLP-1R, thereby promoting mitochondrial biogenesis and enhancing mitochondrial function