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Moreover, recruitment of this triple combination therapy regimen can reduce the incidence of inflammation and skin irritation induced by hydroquinone or retinoids (Gupta et al., 2006)

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Interestingly, a concentrationresponse analysis showed there was a notable difference in activity between each regioisomer of 50ac , suggesting that there may be variations in conformational preferences and/or a preference for retaining a 2-aryl substituent on the 2-position of the benzoxazole, consistent with previous SAR studies 38