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35 , 5670.e53 (2023)

doi:10.1002/jnr.24476 11

At the periphery, the production of neopterin and nitric oxide during inflammation consumes tetrahydrobiopterin to the detriment of the hydroxylase enzymes that use this compound as a cofactor.[ref] Genetic variants can also significantly influence BH4 levels when the body is under stress

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