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Lysosomal destabilizing drug siramesine and the dual tyrosine kinase inhibitor lapatinib induce a synergistic ferroptosis through reduced heme oxygenase-1 (HO-1) levels

[DOI] [PubMed] [Google Scholar] 26.Sebecic B, Nikolic V, Sikiric P, et al

It may be argued that radical scavenging by hydropersulfides is nevertheless limited by their inherent instability, as they are subject to thiol-mediated reduction in the presence of millimolar amounts of GSH (GSSH + GSH GSSG + H 2 S)

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