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In reality, weight loss can include a mix of: fat mass water shifts glycogen depletion lean body mass loss Lean mass includes more than skeletal muscle alone, but from a patient perspective, the concern is practical: if too much muscle is lost during weight reduction, people may feel weaker, recover worse, move less, and potentially struggle more with long-term metabolic maintenance

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The future of obesity treatment is unlikely to be GLP-1 alone

The landscape shifted in November 2025