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These include both exogenous factors, such as maternal exposure to tobacco and alcohol, and endogenous factors, including advanced parental age at conception, oxidative stress, or mitochondrial dysfunction

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The researchers showed that ethanol in a dose-dependent manner led to a significant increase in matrix metalloproteinase-9 (MMP-9) expression, which was significantly correlated with the expression of pro-inflammatory cytokines, such as TNF- and ILS such as IL-1 and IL-6