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We also found that residual disease is related to a higher risk of systemic spreading

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doi:10.1001/jamainternmed.2013.2720 57

however, upon injury, it is rapidly and aberrantly activated, inducing the transdifferentiation of renal interstitial fibroblasts into myofibroblasts, which possess enhanced migratory and proliferative capabilities and synthesize large amounts of ECM